Cytokine gene polymorphism in human disease: on-line databases, Supplement 3

Cytokine Gene Polymorphism in BCG Lymphadenopathy

Background: Tumor necrosis factor-beta or lymphotoxin-alpha (LT-α), IL-4 and IL-10 are determining factors in immunity against BCG.  Allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in BCG containment. Objective: To study the prevalence of –590 (C/T) and –592 (C/A) allelic distribution of IL-4 and IL-10 promo...

cytokine gene polymorphism in bcg lymphadenopathy

background: tumor necrosis factor-beta or lymphotoxin-alpha (lt- α ), il-4 and il-10 are determining factors in immunity against bcg.  allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in bcg containment.   objective : to study the prevalence of –590 (c/t) and –592 (c/a) allelic distribution of il-4 and il-10 ...

Integrin Beta-3 Gene Polymorphism and Risk for Myocardial Infarction in Premature Coronary Disease

Background: Contradictory results have been obtained regarding the role of integrin, beta 3 (ITGB3) gene polymorphisms in occurrence of myocardial infarction (MI). Objectives: We aimed to assess the association between 1565C/T polymorphism of ITGB3 gene and increased risk for acute MI in patients with premature coronary artery disease (CAD). <strong...

Effect of Cyperus Rotundus on Cytokine Gene Expression in Experimental Inflammatory Bowel Disease

Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to ...

Cytokine Gene Polymorphism and Infection